PlayStation 3
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- Saboteur, The
- Sackboy's Prehistoric Moves
- Sacred 2: Fallen Angel
- Saints Row: The Third
- Sam and Max: Beyond Time and Space
- Sam and Max: The Devil's Playhouse Episode 3 - They Stole Max's Brain!
- Sam and Max: The Devil's Playhouse Episode 5 - The City That Dares Not Sleep
- Savage Moon
- Saw
- Saw 2: Flesh and Blood
- SBK 09: Superbike World Championship
- SBK 2011
- SBK Generations
- Scene It? Bright Lights! Big Screen!
- Scene It? Movie Night
- Scott Pilgrim vs. the World
- Secret of Monkey Island, The: Special Edition
- Section 8
- Section 8: Prejudice
- Sega Bass Fishing
- SEGA Rally Online Arcade
- Sega Superstars Tennis
- Sengoku Basara: Samurai Heroes
- Shadow of the Colossus
- Shadows of the Damned
- Shank
- Shank 2
- Shaun White Skateboarding
- Shaun White Snowboarding
- Shift 2: Unleashed
- Shoot Many Robots
- Shoot, The
- Sideway: New York
- Silent Hill: Downpour
- Silent Hill: Homecoming
- Simpsons, The: Game
- Sims 3, The
- Sims 3, The: Pets
- SingStar
- SingStar: ABBA
- SingStar Dance
- SingStar Digital
- SingStar Guitar
- SingStar: Motown
- SingStar: Queen
- SingStar: Take That
- SingStar: Vol. 2
- SingStar: Vol. 3
- Singularity
- Skate
- Skate 2
- Skate 3
- Ski Doo: Snowmobile Challenge
- Skullgirls
- Skydrift
- Skyfighter
- Skylanders Giants
- Skylanders: Spyro's Adventure
- Slam Bolt Scrappers
- Sleeping Dogs
- Sly Collection, The
- Sly Cooper: Thieves in Time
- Smash Cars
- Sniper Elite V2
- Sniper: Ghost Warrior 2
- SOCOM 4: U.S. Navy SEALs
- SOCOM: U.S. Navy SEALs Confrontation
- Soldier of Fortune: Payback
- Soldner-X 2: Final Prototype
- Sonic Adventure
- Sonic Adventure 2
- Sonic and All-Stars Racing Transformed
- Sonic Generations
- Sonic the Fighters
- Sonic the Hedgehog
- Sonic the Hedgehog 4: Episode 1
- Sonic the Hedgehog 4: Episode 2
- Sonic Unleashed
- Sorcery
- Soulcalibur IV
- Soulcalibur V
- Sound Shapes
- Space Ace
- Space Invaders Infinity Gene
- Spare Parts
- Spartacus Legends
- Spec Ops: The Line
- Spelunker Black
- Spelunker HD
- Spider-Man 3
- Spider-Man: Edge of Time
- Spider-Man: Shattered Dimensions
- Spider-Man: Web of Shadows
- Splatterhouse
- Splinter Cell: Double Agent
- Split/Second
- Sports Champions
- Sports Champions 2
- SSX
- Stacking
- Starhawk
- Star Ocean: The Last Hope
- Star Raiders
- Star Trek: D-A-C
- Start the Party!
- Star Wars Pinball
- Star Wars: The Clone Wars - Republic Heroes
- Star Wars: The Force Unleashed
- Star Wars: The Force Unleashed - Ultimate Sith Edition
- Star Wars: The Force Unleashed 2
- Stranglehold
- Street Fighter 3: Third Strike Online Edition
- Street Fighter 4
- Street Fighter X Tekken
- Streets of Rage 2
- Strider
- Strong Bad's Cool Game for Attractive People - Episode 1: Homestar Ruiner
- Stuntman Ignition
- Summer Challenge: Athletics Tournament
- Summer Stars 2012
- SuperCar Challenge
- Super Stacker
- Super Stardust HD
- Superstars V8 Next Challenge
- Superstars V8 Racing
- Super Street Fighter 4
- Super Street Fighter 4: Arcade Edition
- Supremacy MMA
- Surf's Up
- Swarm
- Swords and Soldiers
- Syndicate (2012)